Sleep and circadian rhythms have widespread implications for health and disease.  We're finding a few more:

1)  Our lab's main research focus is on the mechanisms of glial regeneration in murine models of Traumatic Brain Injury (TBI).  We use the circadian clock (i.e. Bmal1) as a tool by which to dissect the molecular underpinnings of the largest population of regenerative cells in the brain: NG2-glia.

2) Using human CSF samples, we aim to characterize the day/night metabolomic changes in plasma and CSF, both in "health" and disease, defining fundamental aspects of brain physiology over time.

3) We also conduct clinical research on sleep in neurocritical illness.  For instance, in pediatric TBI, we found that sleep on EEG within 48 hours after injury is a useful biomarker for predicting better functional outcomes

The Team:
Marina Salinas
Jacob Tusk
(graduated) Javid Ghaemmaghami
(graduated) Emma Strickland
(graduated) Victoria Koffi
(graduated) John Corso

CNH Collaborators:
The Hashimoto-Torii Lab

Remote Collaborators/Mentors:
Amita Sehgal (Perelman School of Medicine at the University of Pennsylvania)
Regina Armstrong (Uniformed Services University)