Sleep in Critical Illness

Despite decades (centuries?) of dedicated effort by some really smart people, we still don't know why we sleep.  We know what happens when we don't.  But that's not the same question.  So why not give it a whirl, ourselves?

Using CSF samples from the Bear Brain Bank, we aim to characterize the day/night metabolomic changes in plasma and CSF, both in "health" and disease, defining fundamental aspects of brain physiology over time.

We also conduct clinical research on sleep in neurocritical illness.  For instance, in pediatric TBI, we found that sleep on EEG within 48 hours after injury is a useful biomarker for predicting better functional outcomes - more coming soon!
CSF Biobank Team:
Daniel Donoho
Akilah Pascall
Jamie Fraser
William Suslovic
Meghan Delaney
... and many more

ICU EEG Research Team:
Akilah Pascall
Dana Harrar
Arnold Sansevere



Akilah S. Pascall, Anqing Zhang, Omar Dughly, D. Harrar, T. Dean

Critical Care Medicine, 2022

The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons.

Daniel J. Cavanaugh, Abigail S Vigderman, Terry Dean, David S. Garbe, A. Sehgal

Sleep, 2016

Drosophila QVR/SSS Modulates the Activation and C-Type Inactivation Kinetics of Shaker K+ Channels

Terry Dean, R. Xu, W. Joiner, A. Sehgal, T. Hoshi

Journal of Neuroscience, 2011

SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker

Mark N. Wu, W. Joiner, Terry Dean, Zhifeng Yue, Corinne J. Smith, Dechun Chen, T. Hoshi, A. Sehgal, K. Koh

Nature Neuroscience, 2009

The effects of dietary iron deprivation on murine circadian sleep architecture.

Terry Dean, R. Allen, C. O'Donnell, C. Earley

Sleep Medicine, 2006

Cognitive deficits associated with restless legs syndrome (RLS).

V. Pearson, R. Allen, Terry Dean, C. Gamaldo, S. Lesage, C. Earley

Sleep Medicine, 2006

Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse.

V. Polotsky, A. E. Rubin, A. Balbir, Terry Dean, Philip L. Smith, A. Schwartz, C. O'Donnell

Sleep Medicine, 2006

Investigation into the correlation between sensation and leg movement in restless legs syndrome

P. Birinyi, R. Allen, S. Lesage, Terry Dean, C. Earley

Movement Disorders, 2005


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